http://pbpk.org/ com_fireboard en-us Thu, 09 Sep 2010 11:13:59 +0100 fb_rsspower.gif http://pbpk.org/ 88 http://pbpk.org//component/option,com_fireboard/Itemid,30/func,view/id,159/catid,24/ Dear All, I doing my Phd in Population Pharmacokinetic of drug. Can anyone guide me how to select drug population pharmacokinetic study. Please guide me. With Regards Raja... http://pbpk.org//component/option,com_fireboard/Itemid,30/func,view/id,158/catid,23/ Hi Everyone I am developing a model for cobalt dispersion in the human body. I am using a acIX software to generate a code but i am unable to get to a conclusion as i am totally new to this field. Please help me with the coding... http://pbpk.org//component/option,com_fireboard/Itemid,30/func,view/id,147/catid,23/ Thank you, Giorgio!... http://pbpk.org//component/option,com_fireboard/Itemid,30/func,view/id,146/catid,23/ I have attached a picture of Table 1 from the free to view pdf of a PBPK model for the monkey requested. To look at whole paper then paste and copy this link into your browser. http://toxsci.oxfordjournals.org/cgi/reprint/53/2/185 If it doesn't work then follow this link http://toxsci.oxfordjournals.org/cgi/content/full/53/2/185 TABLE 1 PBPK Model Parameters for a 4-Compartment Monkey Model for Methanol Model compartment ------------------------------------------------------------------------... http://pbpk.org//component/option,com_fireboard/Itemid,30/func,view/id,145/catid,23/ Dear all, I am trying to build up a monkey PBPK model. Does anyone happen to know any literature with physiological parameters (like, blood flow, organ volume) for cynomolgus monkeys? I can find those information for mice. Thanks a lot,Post edited by: Cwux, at: 2010/03/12 05:05... http://pbpk.org//component/option,com_fireboard/Itemid,30/func,view/id,139/catid,23/ Both in vivo and in vitro ADME/PK study directors sought for Canadian company. Background in animal studies ADME, or cell based assays PK. M.Sc. or Ph.D. in life sciences. Solid scientific background and experience in a study director role. History of helping clients solve analysis problems. Please send email to hr@hessjobs.com Thanks, Paula... http://pbpk.org//component/option,com_fireboard/Itemid,30/func,view/id,133/catid,23/ I am trying to develop PBPK models in a range of pre-clinical species and human, using the Rogers method of determining Kp values using the various tissue compositions in each of the species. Do people know of any useful references that outline the tissue composition (E/C water, Neut lipid, Acidic Phospholipids etc...) for dogs and monkeys. I have rat and human data. ta,... http://pbpk.org//component/option,com_fireboard/Itemid,30/func,view/id,132/catid,24/ pls sen me email to abdeltawab.mossa@yahoo.com to send all information you needs. thanks Abdel-Tawab H. Mossa, Ph.D. pesticide Chemistry and toxicology... http://pbpk.org//component/option,com_fireboard/Itemid,30/func,view/id,116/catid,23/ The problem was in the parameterisation. I had built the model with the muscle as part of the slowly perfused tissue rather than a seperate compartment. However I used the values quoted in the report and did not take into account muscle volume or blood flow hence major error. I assume it uses a mass balance equation for muscle hence the values for muscle are not quoted in the report. A newbie error by myself I take it, I note there have been past forum questions on taking this into account and doing some s... http://pbpk.org//component/option,com_fireboard/Itemid,30/func,view/id,115/catid,23/ Giorgio Unfortunately, it is extremely difficult to help in these circumstances because this type of problem is certainly due to coding. Debugging is laborious. Have you tried to build the model using MEGen? If not click on Build a Model on the left hand panel above. You should be able to export the model in ACSL code. George...