HSL is to run a two-day course on the Derivation of a Derived No-Effect Level Using PBPK and Benchmark Dose Response Modelling.

The course will be held at the Health and Safety Laboratory, Harpur Hill, Buxton, Derbyshire on the following dates:

Monday 12 October 2009 – Tuesday 13 October 2009

The course will cover:

• Tools for use in quantitative, data-informed chemical risk assessment.
• An approach for the derivation of a DNEL for a chemical with a demonstrable threshold.
• The fundamental concepts underlying PBPK modelling.
• The rapid construction of PBPK models using a user-friendly model equation generator and visualizing model output using the software, Berkeley Madonna®.

Who should attend?

• Industrial professionals responsible for conducting or evaluating risk assessments on consumer, environmental and occupational exposure to chemicals.
• Occupational health and safety professionals.
• Scientists interested in physiologically based pharmacokinetic modelling.

Venue

The course will be run at the HSL laboratory in the spa town of Buxton. Buxton is in the heart of the Peak District and has good links to mainline train stations and Manchester International Airport.

The cost of the two-day course is £995 + VAT (includes course notes, lunches, dinner on the Monday night and all refreshments).

For further information Click here or contact the Training Unit at HSL directly on +44 1298 218806.

Eurotox 2009 - Dresden, Germany 

Symposium 6 (WHO/International Programme on Chemical Safety) Tuesday, September 15

The increasing use of pharmacokinetic models in chemical risk assessments is recognised. It is necessary to develop a common understanding of what constituents are required to develop an internationally acceptable model and how to validate it. A common understanding would facilitate sharing of models and model evaluations as well as consistent application in risk assessments. Consideration will be given to:

1) Model development,
2) Model characterization, i.e. methods to describe how consistent the model is with biology; strengths and limitations of available model and data, such as sensitivity analyses,
3) Model documentation,
4) Model evaluation, i.e. independent review.

Presentations by

Dr. Bette Meek, Canada, Prof. Dr. Ursula Gundert-Remy, Germany, Dr. George Loizou, UK, Dr. Harvey J. Clewell III, USA, Dr. Olavi Pelkonen, Finland

Human Alternatives to Animal Studies

To mark the 40^th  Anniversary of the establishment of FRAME (Fund for the Replacement of Animals in Medical Experiments) and its 30 years of collaboration with the University of Nottingham

Tuesday 8 September to Thursday 10 September

Jubilee Campus

University of Nottingham

FRAME is staging a three-day symposium on the subject of Human Alternatives to Animal Studies. Topics to be covered include human tissue engineering, computer-based studies, clinical studies, human cell-based studies and organotypic models based on human cells and tissues. The event will feature established speakers as well as offering new researchers the opportunity to present their work

The conference will bring academic and pharmaceutical industry scientists together, to discuss how human cells and tissues can be ethically acquired and used in fundamental research and the development of new medicines and other therapies.

For more details and to download a booking form, log on to FRAME